This article is a disambiguation page for Mrs. Osborne
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- Celia Osborne, the wife of Jack Osborne until 1997.
- Jill Osborne, the wife of Jack Osborne from 1998 to 2000.
- Frankie Osborne, the wife of Jack Osborne from 2005 to 2017.
- Nancy Osborne, the wife of Darren Osborne since 2012.