Manchester is a city in North-West England, home to 553,230 citizens in 2019.
- The Ashworth family moved to Hollyoaks from Manchester in September 2005.
- In November 2010, Amy Barnes recovered in a hospital in Manchester after suffering serious injuries in the Il Gnosh fire.
- In January 2011, Eva Strong intended to move to Manchester with daughter Anita Roy, but Anita changed her mind and Eva left alone.
- In July 2012, Pete Buchanan slept with thirteen-year-old Cleo McQueen in Fairview Hotel in Manchester.
- In March 2015, Kim Butterfield transferred girlfriend Esther Bloom to a hospital in Manchester to get her away from Grace Black.
- In September 2017, Mike Barnes moved to Manchester.
- In November 2017, Mac Nightingale was sent to a long-term care facility in Manchester as he was suffering from locked-in syndrome as a result of being pushed through a window by his daughter, Ellie.
- In July 2018, Tony Hutchinson turned up on the doorstep of his ex-fiancée Julie Matthews, who resided in Manchester.
- In April 2020, Felix Westwood revealed that he had a son named DeMarcus Westwood, who resided in Manchester with his mother.