Holby City was a medical drama created by Tony McHale and Mal Young. The series ran from 12th January 1999 to 29th March 2022.
Holby - the fictional city in which Holby City is set - exists in the same universe as Hollyoaks. In Episode 5713 (3rd November 2021), Cindy Cunningham shows Ripley Lennox and Brooke Hathaway a news article about a terminally ill cancer patient named Sammy Harrington, who appeared in episode 31 of series 23 of Holby City.
Out of the regular Hollyoaks cast, actor Jeremy Edwards played the regular role of Danny Shaughnessy from 1999 to 2003, Jeremy Sheffield played Alex Adams from 2000 to 2003, and David Ames portrayed Dominic Copeland from 2013 to 2022.