Annalise Appleton, played by Tamaryn Payne, debuted on-screen on 26 September 2011. The character was introduced as one of five new students who arrive to study at Hollyoaks Community College. Payne said her audition for the serial was the first time she attempted to get into television. She said the whole experience had been "amazing Entertainment website Digital Spy first announced the character of Annalise on 5 September 2011. The Hollyoaks press office said that the students are "possibly the coolest set" to ever feature in the serial because they "shake things up" and face "life's hardest lessons".
Annalise arrives at HCC with Rob and meets her flat share students Scott Sabeka (Calvin Denba), Will Savage (James Atherton) and Barney Harper-McBride (Tom Scurr). Annalise becomes annoyed with Rob when he dares Ash Kane (Holly Weston) to trip off in front of the crowd in the SU Bar. When Rob forgets to keep his plans with Annalise and she tires of his partying. She accuses him of not caring about her and forces him to sleep on the sofa. Rob forgets about his two-year anniversary with Annalise, he offers to make it up to her by allowing her to organise a party at the SU Bar. Annalise is happy to do so and becomes fixated on making the party run smoothly. Annalise asks Rob to make some invitations for the party, when she receives them she realises that Scott has actually made them. She bonds with Scott who tells her that Rob is treating her unfairly. Rob fails to turn up to their anniversary party and tells Annalise he will make it up to her. When Rob does not appear again, she talks to Scott about her problems and the two nearly kiss. However the are interrupted by the police who inform Annalise that Rob has been run over. She feels bad and rushes to Rob's side to support him.
Soon after all the students move out of HCC halls and Annalise and Scott get a flat together, however after realising they wouldn't work out Scott left alone for Thailand. Annalise is later caught in a bus crash at a wedding she helped to organise. She also suggests some new business ideas to Mitzeee and her sister Maxine Minniver in Chez Chez. Rob and Annalise then leave Hollyoaks to start a new life in London.
Annalise has a scene in the intro where she faces a messy room, turns her head and snaps her fingers, and all the items in the room are cleaned up and organized.