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- 1995 - First appearance of Cindy Cunningham.
- 2006 - Adam Tyler and Millie Andrews marry as do Precious and Troy.
- 2014 - Maxine Blake is found not guilty of the attempted murder of Patrick Blake. Theresa McQueen goes into respiratory arrest after donating a kidney to Nico Blake.
- 2017 - Mac Nightingale is transferred to a care home. Dirk Savage cheats on Cindy Cunningham with Myra McQueen.
Real life events
Episodes aired on 4th December in the following years:
- 1990s - 1995, 1997
- 2000s - 2000, 2001, 2003, 2006, 2007, 2008, 2009
- 2010s - 2012, 2013, 2014, 2015, 2017, 2018, 2019
- Spin-offs - Hollyoaks: In The City (Episode 17)