Doctor Strange in The Multiverse o Madness - The Loop
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- Breda McQueen is born.
- 1987 - Carmel Valentine is born.
- 2011 - Darren Osborne proposes to Nancy Hayton, who accepts. Suzanne Ashworth gives birth to twins, whom she names Jack and Francine Osborne. Tom Cunningham beats Esther Bloom unconscious with a cricket bat upon discovering her breaking into his family's home.
- 2013 - Esther Bloom attempts suicide in The Folly by overdosing on pills and vodka, causing her to collapse. Frankie Osborne reports Esther missing, but she is found the next morning by George Smith. Frankie later finds pills in Esther's bag and realises Esther has attempted suicide. She collapses and is rushed to hospital.
- 2020 - Jesse Donovan collapses from alcohol poisoning caused by binge drinking.
- 2021 - Walter Deveraux collapses due to kidney problems.
Real life events
- 1967 - Tony Hirst (Mike Barnes) is born.
- 2011 - Hollyoaks's 3,000th episode is transmitted.
- 2020 - Hannah Sowden's first episode as series producer since Episode 5341 airs.
Episodes aired on 21st January in the following years:
- 1990s - 1999
- 2000s - 2002, 2003, 2004, 2005, 2008, 2009
- 2010s - 2010, 2011, 2013, 2014, 2015, 2016, 2019
- 2020s - 2020, 2021, 2022