2005 was Hollyoaks's eleventh year of production.
- 8th February - Louise Summers arrives in the village much to Darren Osborne's surprise. (First appearance of the character)
- 31st May - Steph Dean is confronted by the ghost of Michelle Reid, one of Toby Mills's murder victims who was murdered in July 2003, as well as Michelle's boyfriend, Simon Maloney. During the confrontation, Steph falls off the bridge and nearly drowns. Michelle's undiscovered body rises to the surface of the river.
- 8th August - Andy Holt arrives as a student at Hollyoaks Community College. (First appearance of the character)
- 18th August - Ali Taylor stabs Stephen Mackintosh in self defense, killing him. However, whilst fleeing the scene, Ali is struck by a car.
- 19th August - Ali Taylor dies from his injuries sustained after being hit by a car. (Final appearance of the character)
- 8th September - Dannii Carbone is raped by Andy Holt after he spikes her drink with GHB.
- 21st October - Grace Hutchinson is born to Mandy and Tony Hutchinson.
- 14th November - Justin Burton's trial for the murder of Stephen Mackintosh begins.
- 18th November - Justin Burton is found not guilty of the murder of Stephen Mackintosh.
- 9th December - Freddy Watson sets fire to the Hollyoaks Community College media lab.
- 22nd December - Zara Morgan and Lee Hunter leave the village for Thailand. (Last appearance of Lee until 2010 and final appearance of Zara). Les and Sally Hunter move to Cyprus. (Final appearance of the characters)
- 26th December - Clare Devine is hired as The Loft's event supervisor. (First appearance of the character)
- 30th December - Mel Burton collapses from alcohol poisoning.
Real life eventsEdit
- 5th September - The first episode of Hollyoaks: Crossing the Line is aired.
- 8th September - The final episode of Hollyoaks: Crossing the Line is aired.
- 12th September - The first episode of Hollyoaks: Let Loose is aired.
- 12th December - The final episode of Hollyoaks: Let Loose is aired.
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